Impact of ibrutinib on inflammation in a mouse model of Graves’ orbitopathy
The GO mouse model demonstrated enhanced BTK and ITK expression. Ibrutinib, a BTK/ITK inhibitor, suppressed the inflammatory cytokine production. These findings highlight the potential involvement of BTK/ITK in the inflammatory pathogenesis of GO, suggesting its role as a novel therapeutic target.
Authors
- Charm Kim
- Sun Young Jang (ORCID: https://orcid.org/0000-0002-4723-3712)
- Hyung Oh Jun
- Yeon Jeong Choi
- Jin Sook Yoon (ORCID: https://orcid.org/0000-0002-8751-9467)
- Tae Kwann Park (ORCID: https://orcid.org/0000-0001-9689-4384)
- Jin Kwon Chung (ORCID: https://orcid.org/0000-0002-3234-2190)
- Jae Wook Yang (ORCID: https://orcid.org/0000-0001-5163-129X)
- Jin Hwan Park
Institutions
- Yonsei University (KR)
- Eulji University (KR)
- Soonchunhyang University (KR)
- Severance Hospital (KR)
- Soonchunhyang University Hospital Seoul (KR)
- Inje University Busan Paik Hospital (KR)
- Bucheon University (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fendo.2024.1420024
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- National Research Foundation
- Soonchunhyang University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea