Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma
We found that the low retention rate of AFG may be partially ascribed to the reduced pool of interstitial progenitor cells (CD55<sup>high</sup>) present within the ASC population in patients with LoS. We demonstrated the potential for improving the efficacy of AFG in the treatment of LoS by restoring the pool of interstitial progenitors within ASCs. Our study has significant implications for the field of translational regenerative medicine.
Authors
- Meng Yuan (ORCID: https://orcid.org/0000-0002-1158-0595)
- Xiao Long (ORCID: https://orcid.org/0000-0003-0136-2508)
- Nanze Yu (ORCID: https://orcid.org/0000-0003-4312-6036)
- Zhujun Li (ORCID: https://orcid.org/0000-0003-1978-432X)
- Jie Chen (ORCID: https://orcid.org/0000-0001-6960-8354)
- Zhou Zhou (ORCID: https://orcid.org/0000-0002-1060-0355)
- Chenyu Wang (ORCID: https://orcid.org/0000-0002-2958-1588)
- Jiuzuo Huang (ORCID: https://orcid.org/0000-0002-0458-9006)
- Xuanyu Liu (ORCID: https://orcid.org/0009-0005-3141-7858)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s11658-024-00635-0
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking Union Medical College Hospital
- Peking Union Medical College