Biological comparisons between pre-eclampsia and placenta accreta spectrum
Abstract Placenta Accreta Spectrum (PAS) and pre-eclampsia are obstetric disorders associated with significant maternal morbidity and mortality. As pre-eclampsia is characterised by shallow placental invasion and PAS by abnormally deep invasion, we sought to compare the biological processes dysregulated in PAS to those reported in pre-eclampsia. We demonstrate that many of the processes contributing to unregulated placental invasion in PAS are the mirror findings of those previously reported in pre-eclampsia. These comparisons of PAS to a more common obstetric condition allow a greater understanding of the biological processes contributing to PAS, which remains a very rare obstetric complication.
Authors
- Constance Young
- Paul Downey (ORCID: https://orcid.org/0000-0002-9890-4678)
- Vadim Zhernovkov (ORCID: https://orcid.org/0000-0001-8903-1142)
- Kathleen M. Curran (ORCID: https://orcid.org/0000-0003-0095-9337)
- Helena C. Bartels (ORCID: https://orcid.org/0000-0002-6470-9364)
- Walter Kölch (ORCID: https://orcid.org/0000-0001-5777-5016)
- Aurélie Fabre (ORCID: https://orcid.org/0000-0001-8176-1386)
- Donal J. Brennan (ORCID: https://orcid.org/0000-0002-6747-3342)
- Myriam Nabhan (ORCID: https://orcid.org/0000-0002-1591-6391)
- Janet McCormack (ORCID: https://orcid.org/0000-0001-6368-5295)
- Sodiq Hameed
Institutions
- University College Dublin (IE)
- Mater Misericordiae University Hospital (IE)
- St. Vincent's University Hospital (IE)
- National Maternity Hospital (IE)
Publication Details
- Journal
- npj Women s Health
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1038/s44294-024-00034-y
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75