Single‐cell multi‐modal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma
scCPA-Tag offers a highly efficient and high throughput technique to simultaneously profile histone modification and chromatin accessibility within a single cell. scCPA-Tag enables to uncover multiple epigenetic modification features of cellular compositions within tumor tissues. scCPA-Tag facilitates the exploration of the epigenetic landscapes of heterogeneous cell types and provides the mechanisms governing gene expression regulation.
Authors
- Yun‐Fan Sun (ORCID: https://orcid.org/0000-0001-9790-2761)
- Yinqi Bai (ORCID: https://orcid.org/0000-0003-1017-5712)
- Chuanyu Liu (ORCID: https://orcid.org/0000-0003-2258-0897)
- Longqi Liu (ORCID: https://orcid.org/0000-0002-5828-5542)
- Jianhua Yin (ORCID: https://orcid.org/0000-0003-1207-7788)
- Yaling Huang (ORCID: https://orcid.org/0000-0003-1408-5490)
- Qiuting Deng (ORCID: https://orcid.org/0009-0000-3245-8954)
- Waidong Huang (ORCID: https://orcid.org/0009-0001-6125-0148)
- Zihao Li (ORCID: https://orcid.org/0009-0001-1154-4789)
- Xin Jin (ORCID: https://orcid.org/0000-0001-7554-4975)
- Jie Li (ORCID: https://orcid.org/0000-0002-2773-6806)
- Xun Xu (ORCID: https://orcid.org/0000-0002-5338-5173)
- Liang Wu (ORCID: https://orcid.org/0000-0001-6259-261X)
- Xi Chen (ORCID: https://orcid.org/0000-0002-3817-0422)
- Kaiqian Zhou (ORCID: https://orcid.org/0000-0002-2763-5976)
- Yue Yuan (ORCID: https://orcid.org/0000-0002-5084-6712)
- Chunqing Wang (ORCID: https://orcid.org/0000-0002-2811-7230)
- Miaomiao Jiang (ORCID: https://orcid.org/0000-0002-4737-7564)
- Xuanxuan Zou
- Shanshan Wang (ORCID: https://orcid.org/0009-0001-0101-3642)
- Shiping Liu
- Shang Liu
- Yu Zhong (ORCID: https://orcid.org/0000-0001-5728-871X)
Institutions
- BGI Group (China) (CN)
- Hubei University of Medicine (CN)
- Shanxi Medical University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/ctm2.70000
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China