Food and bile micelle binding of zwitterionic antihistamine drugs
Despite being zwitterion at pH 6.5, the antihistamine drugs were bound to bile micelles. Bile micelle and food binding were suggested to cause a negative food effect on the oral absorption of these drugs. However, the AUC ratio was not quantitatively predicted by using FeSSIF + BFH.
Authors
- Kiyohiko Sugano (ORCID: https://orcid.org/0000-0001-5652-1786)
- Rie Takeuchi
Institutions
- Ritsumeikan University (JP)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2024-08-29
- DOI
- https://doi.org/10.5599/admet.2454
- Citations
- 2
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.42