Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study
This study identified 18 mitochondrial-related genes causally associated with T2DM at multi-omics levels, enhancing the understanding of mitochondrial dysfunction in T2DM and its complications. <i>TUFM</i>, <i>HIBCH</i>, and <i>ISCA2</i> emerge as potential therapeutic targets for T2DM and its complications.
Authors
- Fangting Lu
- Yang Li (ORCID: https://orcid.org/0009-0003-3428-454X)
- Yahu Miao (ORCID: https://orcid.org/0000-0003-3848-965X)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-6377-3890)
- Yijing Chen (ORCID: https://orcid.org/0000-0001-8109-2207)
- Qing Feng (ORCID: https://orcid.org/0009-0001-7216-6742)
- Qiu Zhang (ORCID: https://orcid.org/0000-0002-0204-3528)
- Qingqing Kang
- Weixi Zhu
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fendo.2024.1401531
- Citations
- 10
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 3.27