Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS
ARDS is associated with a numerical deficiency but functional activation of circulating NKT cells, showing impaired responses to α-GalCer and altered interactions with immune cells. The increase in NKT cells within BALF suggests their role in inducing inflammation and remodeling/fibrosis, highlighting the potential of targeting NKT cells as a therapeutic approach for ARDS.
Authors
- Yong-Wook Park (ORCID: https://orcid.org/0000-0002-6937-7119)
- Tae-Ok Kim (ORCID: https://orcid.org/0000-0002-0922-9472)
- Young Goun Jo (ORCID: https://orcid.org/0000-0002-4418-2729)
- Hye‐Mi Jin (ORCID: https://orcid.org/0000-0002-3622-5995)
- Ki‐Jeong Park (ORCID: https://orcid.org/0000-0002-9742-0743)
- Young‐Nan Cho (ORCID: https://orcid.org/0000-0001-6922-8570)
- Hong‐Joon Shin (ORCID: https://orcid.org/0000-0002-0146-3491)
- Bo Gun Kho
- Seung‐Jung Kee (ORCID: https://orcid.org/0000-0001-9708-5837)
Institutions
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fimmu.2024.1433028
- Citations
- 2
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Research Foundation
- Chonnam National University
- National Research Foundation of Korea