Hepatitis B virus X protein differentially regulates the angiogenesis of Hepatocellular Carcinoma through p53-VEGF axis according to glucose levels
These data suggest that the dual roles of HBx confer hepatoma cells to remain in a glucose-rich environment and escape from the glucose-low milieu through tumor vessels, promoting liver tumor progression overall. We exclusively revealed the dual role of HBx on the angiogenesis of liver tumors, which may shed new light on the mechanism and management strategy of HBV- and DM-related hepatocellular carcinoma.
Authors
- Rongfeng Huang
- Guitao Xiao
- Zhixin Chen (ORCID: https://orcid.org/0000-0001-9222-9037)
- Yuehong Huang (ORCID: https://orcid.org/0000-0001-7134-719X)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0001-8152-8971)
- Xiaoyun Huang (ORCID: https://orcid.org/0000-0002-5363-0976)
- Tingxuan Huang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.aohep.2024.101543
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian Provincial Department of Science and Technology
- Fujian Medical University