The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction
Mechanistically, IL-1β enhanced PAI-1 expression in 4G4G endothelial cells, preventing the generation of plasmin and cleavage products like angiostatin, soluble uPAR, and VCAM1. We identified inflammation-induced endothelial dysfunction coupled with fibrinolytic system overactivation as a risk factor for patients with the 5G5G genotype.
Authors
- Satoshi Takahashi (ORCID: https://orcid.org/0009-0006-0733-6094)
- Ricardo A. Rios (ORCID: https://orcid.org/0000-0003-1449-4745)
- Nobutaka Hattori (ORCID: https://orcid.org/0000-0002-2034-2556)
- Tatiane Nogueira
- Eisuke Adachi
- Tetiana Yatsenko (ORCID: https://orcid.org/0000-0001-8601-1939)
- Yousef Salama (ORCID: https://orcid.org/0000-0001-6254-6381)
- Taro Osada (ORCID: https://orcid.org/0000-0002-2260-8047)
- Toshio Naito (ORCID: https://orcid.org/0000-0003-1646-9930)
- Beate Heissig (ORCID: https://orcid.org/0000-0002-0348-5934)
- Koichi Hattori (ORCID: https://orcid.org/0000-0002-5851-8537)
- Kazuhisa Takahashi (ORCID: https://orcid.org/0000-0001-5749-4118)
- Yoko Tabe
Institutions
- Universidade Federal da Bahia (BR)
- National Academy of Sciences of Ukraine (UA)
- An-Najah National University (PS)
- Juntendo University (JP)
- Juntendo University Urayasu Hospital (JP)
- Palladin Institute of Biochemistry (UA)
- The University of Tokyo (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fimmu.2024.1445294
- Citations
- 6
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.44