Downregulation of malic enzyme 3 facilitates progression of gastric carcinoma via regulating intracellular oxidative stress and hypoxia-inducible factor-1α stabilization
We provide evidence that ME3 downregulation is associated with poor prognosis in GC patients and propose a hypothesis for the ME3 regulatory mechanism in GC progression. The present study is of great scientific significance and clinical value for exploring the prognostic and therapeutic targets of GC, evaluating and improving the clinical efficacy of patients, reducing recurrence and metastasis, and improving the prognosis and quality of life of patients.
Authors
- Lisong Teng (ORCID: https://orcid.org/0000-0001-6470-9017)
- Yan Yang (ORCID: https://orcid.org/0000-0003-1070-9614)
- Xun Hu (ORCID: https://orcid.org/0000-0002-3784-371X)
- Xiangliu Chen
- Yiran Chen (ORCID: https://orcid.org/0000-0002-1486-8412)
- Xiadong Lv
- Haiyong Wang (ORCID: https://orcid.org/0000-0003-0124-5301)
- Yingying Huang (ORCID: https://orcid.org/0000-0003-2639-803X)
- Siying Zeng
Institutions
- Guangzhou First People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1007/s00018-024-05388-9
- Citations
- 6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.71