Clinical pathological significance and biological function of PLIN1 in hepatocellular carcinoma: bioinformatics analysis and in vitro experiments
The present study revealed that PLIN1 downregulation is associated with poor prognosis in HCC patients and accelerated HCC progression by promoting cellular proliferation, migration, and metastasis, as well as the mechanisms underlying the regulation of lipid metabolism-related pathways in HCC.
Authors
- Jianghua Huang (ORCID: https://orcid.org/0000-0003-0437-1303)
- Zhen Fang (ORCID: https://orcid.org/0000-0002-7073-8997)
- Liping Zeng (ORCID: https://orcid.org/0000-0002-3579-9145)
- Yu Cong (ORCID: https://orcid.org/0000-0001-5544-1303)
- Zhen‐Bo Feng (ORCID: https://orcid.org/0000-0001-6361-4198)
- Yan Wei
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Guangxi Medical University (CN)
- Hunan University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s12885-024-12842-1
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Natural Science Foundation of China