Exendin-4-enriched exosomes from hUCMSCs alleviate diabetic nephropathy via gut microbiota and immune modulation
This study elucidates a novel therapeutic mechanism of Ex-4-loaded hUCMSCs exosomes in DN, highlighting the induction of CD4<sup>+</sup> Treg cells mediated by specific gut microbiota components. These findings underscore the potential of leveraging gut microbiota and immune cell interplay in developing effective DN treatments.
Authors
- Aihua Liang (ORCID: https://orcid.org/0000-0002-5798-4405)
- Jukai Huang
- Liping Wang (ORCID: https://orcid.org/0000-0003-4648-8155)
Institutions
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- China Academy of Chinese Medical Sciences (CN)
- Institute of Chinese Materia Medica
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fmicb.2024.1399632
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34