Britannilactone 1-O-acetate induced ubiquitination of NLRP3 inflammasome through TRIM31 as a protective mechanism against reflux esophagitis-induced esophageal injury
Brt promotes the ubiquitination of NLRP3 through TRIM31 and attenuates esophageal epithelial damage induced by RE caused by acidic bile salt exposure. This study provides valuable insights into the mechanism of action of Brt in the treatment of RE and highlights its promising application in the prevention of NLRP3 inflammatory vesicle-associated inflammatory pathological injury.
Authors
- Manman Guo (ORCID: https://orcid.org/0000-0002-7928-8902)
- Yun‐Yan Xu
- Yi Wang (ORCID: https://orcid.org/0000-0002-9248-5732)
- Ju Liu (ORCID: https://orcid.org/0000-0002-4530-0950)
- Yun Hu (ORCID: https://orcid.org/0000-0003-0501-4009)
- Yan Wang
- Qianfei Xu
- Yang Xiao
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s13020-024-00986-y
- Citations
- 4
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.86
Funders
- Government of Jiangsu Province
- Nanjing University of Chinese Medicine
- Nanjing University