A Thorough Examination of Peltophorum pterocarpum Phytochemicals in Network Pharmacology-Based Management of Acne Vulgaris

Introduction Acne vulgaris is a common skin problem caused by inflammation of the sebaceous glands and hair follicles as a result of hormonal fluctuations, bacteria, and overproduction of oil. The plant <i>Peltophorum pterocarpum</i> (<i>P. pterocarpum</i>) has been investigated for possible medical uses. Its anti-inflammatory, antibacterial, and antioxidant qualities are well recognised, and they may be applied to treat several diseases. This study investigates the plant's phytochemicals for their effectiveness in treating acne. Methods The Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT) database was utilised to extract the phytochemicals from <i>P. pterocarpum</i>. The absorption, distribution, metabolism, and excretion (ADME) analysis was conducted using the online tool SwissADME. The SwissTargetPrediction tool determines the potential targets of these phytochemicals. Targets for acne have been identified using the Open Targets Platform database. The common targets of <i>P. pterocarpum</i> and acne were identified using the Venn diagram drawing tool Venny 2.1.0, and a protein-protein interaction (PPI) network was built using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database. Following that, hub genes were identified by Cytoscape 3.10.2. The web tool ShinyGO 0.80 has enabled simpler evaluation of enrichment analysis for these hub genes. Results Five genes were shown to be key targets because they are directly engaged in the relaxin signalling pathway by pathway analysis: epidermal growth factor receptor (EGFR) and various matrix metalloproteinases (MMPs) (MMP1, MMP2, MMP9, and MMP13). The phytochemicals found in <i>P. pterocarpum</i>, including quercetin, rhamnetin, hirsutidin, and (+)-leucocyanidin, target these key genes. Conclusion This study highlights the potential of <i>P. pterocarpum</i> as a multi-target therapeutic agent for acne vulgaris. By targeting key genes in the relaxin signalling pathway, the phytochemicals from <i>P. pterocarpum</i> present a promising approach for acne management.