Sini san regulates intestinal flora and short-chain fatty acids to ameliorate hepatocyte apoptosis and relieve CCl4-induced liver fibrosis in mice
In conclusion, our experimental results suggest that the disturbance in intestinal flora results in elevated SCFA levels, which further exacerbates hepatocyte apoptosis in liver fibrosis, while SNS suppresses CCl<sub>4</sub>-induced liver fibrosis at least partially by reinstating intestinal flora homeostasis and reducing SCFA levels.
Authors
- Luyun Chen (ORCID: https://orcid.org/0000-0002-7749-9052)
- Yong Su (ORCID: https://orcid.org/0000-0003-1964-0756)
- Chaoliang Ge (ORCID: https://orcid.org/0000-0002-0082-1146)
- Qiong Wu (ORCID: https://orcid.org/0009-0006-9223-2467)
- Yu Yao
- Yijie Ding
- Fangsi Zhu
Institutions
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fphar.2024.1408459
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- China Pharmaceutical University