Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis
Hepatocyte-derived FGF21 mediates liver-muscle crosstalk, which impairs muscle regeneration via the inhibition of the PI3K/Akt pathway, thereby demonstrating a novel therapeutic strategy for DC-related sarcopenia.
Authors
- Da Zhou (ORCID: https://orcid.org/0000-0003-3062-5952)
- Xuejin Gao (ORCID: https://orcid.org/0000-0003-1474-4214)
- Junbo Zuo (ORCID: https://orcid.org/0009-0005-3196-574X)
- Donghua Zhang (ORCID: https://orcid.org/0000-0003-2959-9638)
- Li Zhang (ORCID: https://orcid.org/0000-0001-6061-6833)
- Chenghao Zeng
- LongChang Huang
- Gulsudum Mamtawla
- Yifan Shi
- Xinying Wang (ORCID: https://orcid.org/0000-0003-3821-8390)
Institutions
- Jiangsu University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.redox.2024.103333
- Citations
- 10
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Nanjing University
- Jiangsu Provincial Key Research and Development Program