Maternal obesogenic diet during pregnancy and its impact on fetal hepatic function in baboons
Reduced CYP activity in HF-HED males may be driven in part by dampened hepatic-specific glucocorticoid signaling via altered GR isoform expression. These findings highlight targetable mechanisms that may reduce later-life sex-specific disease risk.
Authors
- Hillary F. Huber (ORCID: https://orcid.org/0000-0001-9734-427X)
- Janna Leigh Morrison (ORCID: https://orcid.org/0000-0002-8602-8519)
- Michael D. Wiese (ORCID: https://orcid.org/0000-0002-3255-9242)
- Ashley S. Meakin (ORCID: https://orcid.org/0000-0003-2806-6274)
- Cun Li (ORCID: https://orcid.org/0000-0003-2855-4366)
- Vicki Lee Clifton (ORCID: https://orcid.org/0000-0002-4892-6748)
- Peter W. Nathanielsz (ORCID: https://orcid.org/0000-0003-0802-0084)
Institutions
- University of Wyoming (US)
- Texas Biomedical Research Institute (US)
- The University of Queensland (AU)
- University of South Australia (AU)
- Mater Research (AU)
Publication Details
- Journal
- Obesity
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/oby.24124
- Citations
- 6
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- University of South Australia
- National Institutes of Health
- Australian Research Council