Blood‐derived microRNAs are related to cognitive domains in the general population
We investigated the association of blood-derived microRNAs with cognitive domains. Five previously identified and 14 novel microRNAs were associated with cognition. Eleven cognition-related microRNAs were also associated with cortical thickness. Identified microRNAs were linked to genes associated with neuronal functions. Results provide putative biomarkers or therapeutic targets of cognitive aging.
Authors
- Mohammed Aslam Imtiaz
- André Fischer (ORCID: https://orcid.org/0000-0001-8546-1161)
- Santiago Estrada (ORCID: https://orcid.org/0000-0003-0339-8870)
- N. Ahmad Aziz (ORCID: https://orcid.org/0000-0001-6184-458X)
- Tonatiuh Peña Centeno (ORCID: https://orcid.org/0000-0002-9329-8912)
- D. Krüger (ORCID: https://orcid.org/0000-0003-1950-9547)
- Monique M.B. Breteler (ORCID: https://orcid.org/0000-0002-0626-9305)
- Valentina Talevi (ORCID: https://orcid.org/0000-0003-4418-7439)
- Rika Etteldorf (ORCID: https://orcid.org/0009-0008-6317-7934)
- Konstantinos Melas (ORCID: https://orcid.org/0009-0000-5206-5322)
Institutions
- University of Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/alz.14197
- Citations
- 11
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Helmholtz Association