Leptin signalling altered in infantile nephropathic cystinosis‐related bone disorder
Our findings suggest a significant role for dysregulated leptin signalling in INC-related bone disorder, either directly or potentially involving a muscle-bone interplay. Leptin signalling blockade may represent a novel approach to treating bone disease as well as muscle wasting in INC.
Authors
- Arieh Gertler (ORCID: https://orcid.org/0000-0002-3451-1306)
- Ping Zhou (ORCID: https://orcid.org/0000-0001-9680-1651)
- Eduardo A. Oliveira (ORCID: https://orcid.org/0000-0002-5642-7164)
- Ronghao Zheng
- Robert H. Mak (ORCID: https://orcid.org/0000-0002-8512-9000)
- Wai W. Cheung
Institutions
- Universidade Federal de Minas Gerais (BR)
- Hebrew University of Jerusalem (IL)
- Chengdu Medical College (CN)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Maternal and Child Health Hospital of Sichuan Province (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1002/jcsm.13579
- Citations
- 1
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Cystinosis Research Foundation
- University of Alabama at Birmingham
- University of Alabama
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases