Clinical analysis of immune reconstitution after chemotherapy in children with acute lymphoblastic leukemia
The immune systems of the ALL patients were severely compromised upon therapy withdrawal, particularly the B cells. At six months after the therapy ended, the B cells were basically restored to normal level, while the T-cell compartment was not. The impaired numbers of CD3 + T cell may contribute to a weakened anti-tumor response, potentially leading to a poorer prognosis.
Authors
- Ai Zhang (ORCID: https://orcid.org/0000-0002-9545-1300)
- Qun Hu (ORCID: https://orcid.org/0000-0002-1508-2796)
- Yuting Xu (ORCID: https://orcid.org/0000-0003-2091-3854)
- Aiguo Liu (ORCID: https://orcid.org/0000-0002-8541-1671)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s12887-024-05030-4
- Citations
- 4
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 2.17
Funders
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology