Effect of Semaglutide on Cardiac Structure and Function in Patients With Obesity-Related Heart Failure
In the STEP-HFpEF Program echocardiography substudy, semaglutide appeared to improve adverse cardiac remodeling compared with placebo, further suggesting that treatment with semaglutide may be disease modifying among patients with obesity-related HFpEF. (Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity [STEP-HFpEF]; NCT04788511; Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes [STEP-HFpEF DM]; NCT04916470).
Authors
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Xiaowen Wang (ORCID: https://orcid.org/0000-0002-5374-7832)
- Steen Z. Abildstrøm
- John W. Ostrominski (ORCID: https://orcid.org/0000-0002-2866-9414)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Tuvia Ben‐Gal (ORCID: https://orcid.org/0000-0001-6941-1738)
- Mette Nygaard Einfeldt (ORCID: https://orcid.org/0000-0003-2427-2601)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Julio E. Núñez (ORCID: https://orcid.org/0000-0003-1672-7119)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Hiroshi Ito (ORCID: https://orcid.org/0000-0002-9857-8614)
- Walter P. Abhayaratna (ORCID: https://orcid.org/0000-0002-4908-0641)
- Mikhail Kosiborod (ORCID: https://orcid.org/0000-0002-3750-9789)
- Dalane W. Kitzman (ORCID: https://orcid.org/0009-0000-5274-0826)
- Michele Senni (ORCID: https://orcid.org/0000-0001-5502-7882)
- Fozia Ahmed (ORCID: https://orcid.org/0000-0001-9769-0180)
- Vijay Chopra (ORCID: https://orcid.org/0000-0001-9512-1718)
- Melanie Jane Davies (ORCID: https://orcid.org/0000-0002-9987-9371)
- Béla Péter Merkely (ORCID: https://orcid.org/0000-0001-6514-0723)
- Subodh Verma
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Peter van der Meer (ORCID: https://orcid.org/0000-0002-9705-4413)
- Scott D Solomon
- Søren Rasmussen
Institutions
- Semmelweis University (HU)
- Northwestern University (US)
- Australian National University (AU)
- Brigham and Women's Hospital (US)
- St. Michael's Hospital (CA)
- Mayo Clinic (US)
- University Medical Center Groningen (NL)
- Harvard University (US)
- Tel Aviv University (IL)
- University of Groningen (NL)
- University of Toronto (CA)
- Novo Nordisk (Denmark) (DK)
- Kawasaki Medical School (JP)
- Rabin Medical Center (IL)
- University Medical Center Freiburg (DE)
- Max Super Speciality Hospital (IN)
- University of Mississippi Medical Center (US)
- Hospital Clínico Universitario de Valencia (ES)
- Ospedale Papa Giovanni XXIII (IT)
- Saint Luke's Hospital (US)
- NIHR Leicester Biomedical Research Centre (GB)
- Wake Forest University (US)
- Keele University (GB)
- University of Missouri–Kansas City (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.021
- Citations
- 99
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 39.80
Funders
- Novo Nordisk