Inflammation in Obesity-Related HFpEF
Inflammation is highly prevalent in obesity-related HFpEF. Semaglutide consistently improved HF-related symptoms, physical limitations, and exercise function, and reduced body weight across the categories of baseline CRP. Semaglutide also reduced inflammation, regardless of either baseline CRP or magnitude of weight loss during the trials. (Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity [STEP-HFpEF; NCT04788511]; Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes [STEP HFpEF DM; NCT04916470]).
Authors
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Dirk von Lewinski (ORCID: https://orcid.org/0000-0001-9996-6128)
- Steen Z. Abildstrøm
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Mikhail Kosiborod (ORCID: https://orcid.org/0000-0002-3750-9789)
- Cecilia Rönnbäck
- Dalane W. Kitzman (ORCID: https://orcid.org/0009-0000-5274-0826)
- Michele Senni (ORCID: https://orcid.org/0000-0001-5502-7882)
- Vojtěch Melenovský (ORCID: https://orcid.org/0000-0001-8921-7078)
- Małgorzata Lelonek (ORCID: https://orcid.org/0000-0003-0756-5541)
- Melanie Jane Davies (ORCID: https://orcid.org/0000-0002-9987-9371)
- Karoline Liisberg
- Subodh Verma
Institutions
- Northwestern University (US)
- St. Michael's Hospital (CA)
- Mayo Clinic (US)
- University of Leicester (GB)
- University of Freiburg (DE)
- University of Toronto (CA)
- Novo Nordisk (Denmark) (DK)
- Medical University of Graz (AT)
- University Medical Center Freiburg (DE)
- National Institute for Health and Care Research (GB)
- University of Mississippi (US)
- Ospedale Papa Giovanni XXIII (IT)
- Baylor Medical Center at Garland (US)
- Medical University of Lodz (PL)
- Institute of Clinical and Experimental Medicine (CZ)
- Saint Luke's Hospital (US)
- Research Institute of Dallas (US)
- Baylor Scott & White Health (US)
- NIHR Leicester Biomedical Research Centre (GB)
- Wake Forest University (US)
- University of Milano-Bicocca (IT)
- University of Missouri–Kansas City (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.028
- Citations
- 67
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 26.94
Funders
- European Commission
- Novo Nordisk