Burst Steroid Therapy for Acute Heart Failure: The CORTAHF Randomized, Open-Label, Pilot Trial
In this small open-label study of patients with AHF, burst steroid therapy was associated with reduced inflammation as measured by hsCRP levels at day 7 (primary endpoint). Secondary endpoints showed improved quality of life at day 7 and reduced 90-day risk of death or worsening HF. Large prospective studies are needed to evaluate these findings.
Authors
- Koji Takagi (ORCID: https://orcid.org/0000-0003-0213-1509)
- Hamlet Hayrapetyan (ORCID: https://orcid.org/0000-0002-8764-5623)
- Yonathan Freund (ORCID: https://orcid.org/0000-0002-0262-3848)
- Malha Sadoune
- Gerasimos S Filippatos (ORCID: https://orcid.org/0000-0002-5640-0332)
- Maria Novosadova
- Chris Edwards (ORCID: https://orcid.org/0000-0002-0585-2697)
- Marco Metra (ORCID: https://orcid.org/0000-0001-6691-8568)
- Ovidiu Chioncel (ORCID: https://orcid.org/0000-0002-3197-3628)
- Gad Cotter (ORCID: https://orcid.org/0000-0002-9613-3339)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Jan Biegus (ORCID: https://orcid.org/0000-0001-9977-7722)
- Tabassome Simon (ORCID: https://orcid.org/0000-0002-4550-0450)
- Douglas L. Mann (ORCID: https://orcid.org/0000-0002-2516-0145)
- Alain Cohen‐Solal (ORCID: https://orcid.org/0000-0003-1055-2231)
- Alexandre Mebazaa (ORCID: https://orcid.org/0000-0001-8715-7753)
- Matteo Pagnesi (ORCID: https://orcid.org/0000-0002-9298-7871)
- Jozine M. ter Maaten (ORCID: https://orcid.org/0000-0002-4910-9336)
- Andranik Mshetsyan
- Drambyan Mayranush
- Beth A. Davison
- Piotr Ponikowski
Institutions
- University Medical Center Groningen (NL)
- Inserm (FR)
- Carol Davila University of Medicine and Pharmacy (RO)
- University of Groningen (NL)
- Université Sorbonne Nouvelle (FR)
- National and Kapodistrian University of Athens (GR)
- Washington University in St. Louis (US)
- Université Paris Cité (FR)
- Wroclaw Medical University (PL)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Mikaelyan Institute of Surgery (AM)
- Hôpital Saint-Antoine (FR)
- Surgical Specialties (Canada) (CA)
- Hôpital Lariboisière (FR)
- Pitié-Salpêtrière Hospital (FR)
- Erebouni Medical Center (AM)
- Momentum Research (US)
- Women's Health Initiative (US)
- Yerevan State Medical University (AM)
- University of Brescia (IT)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1002/ejhf.3452
- Citations
- 24
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.65
Funders
- Institut National de la Santé et de la Recherche Médicale
- Rijksuniversiteit Groningen