The Effect of Semaglutide on Mortality and COVID-19–Related Deaths
Compared to placebo, patients treated with semaglutide 2.4 mg had lower rates of all-cause death, driven similarly by CV and non-CV death. The lower rate of non-CV death with semaglutide was predominantly because of fewer infectious deaths. These findings highlight the effect of semaglutide on mortality across a broad population of patients with CV disease and obesity. (Semaglutide Effects on Cardiovascular Outcomes in Patients With Overweight or Obesity [SELECT]; NCT03574597).
Authors
- Ildiko Lingvay (ORCID: https://orcid.org/0000-0001-7006-7401)
- A. Michael Lincoff (ORCID: https://orcid.org/0000-0001-8175-2121)
- Helen M. Colhoun (ORCID: https://orcid.org/0000-0002-8345-3288)
- Ana Laura de Souza Almeida Matos (ORCID: https://orcid.org/0000-0001-9756-9778)
- Hermann Toplak (ORCID: https://orcid.org/0000-0002-7513-5167)
- John Eric Deanfield (ORCID: https://orcid.org/0000-0001-8806-6052)
- М. В. Ежов (ORCID: https://orcid.org/0000-0002-1518-6552)
- Benjamin M. Scirica (ORCID: https://orcid.org/0000-0002-7093-7048)
- Peter Weeke (ORCID: https://orcid.org/0000-0001-9854-8864)
- Silvio Buscemi (ORCID: https://orcid.org/0000-0003-0730-7649)
- Koichi Node (ORCID: https://orcid.org/0000-0002-2534-0939)
- Ole Kleist Jeppesen
- André P. van Beek (ORCID: https://orcid.org/0000-0002-0335-8177)
- Paweł Bogdański (ORCID: https://orcid.org/0000-0002-0563-1624)
- Søren Hardt‐Lindberg
- Anca-Elena Crăciun
- Donna H. Ryan (ORCID: https://orcid.org/0000-0001-8374-2277)
- Stephen D. Wiviott (ORCID: https://orcid.org/0000-0002-4922-9880)
- Francois Schiele
Institutions
- Pennington Biomedical Research Center (US)
- Poznan University of Medical Sciences (PL)
- Brigham and Women's Hospital (US)
- University Medical Center Groningen (NL)
- Harvard University (US)
- University of Groningen (NL)
- Saga University (JP)
- Novo Nordisk (Denmark) (DK)
- Medical University of Graz (AT)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Edinburgh Cancer Research (GB)
- Cleveland Clinic Lerner College of Medicine (US)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- National Medical Research Center of Cardiology (RU)
- Thrombolysis in Myocardial Infarction Study Group (US)
- University College London (GB)
- The University of Texas Southwestern Medical Center (US)
- University of Palermo (IT)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.007
- Citations
- 39
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 13.95
Funders
- Novo Nordisk