The Effects of Mucolytic Agents N-Acetylcysteine and Erdosteine on Hemostasis in Humans
The levels of factor II significantly decreased, and the platelet count significantly increased in patients treated with erdosteine. D-dimer levels reduced and factor VII levels increased in patients treated with N-acetylcysteine, but these changes were not significant (p=0.069 and p=0.062, respectively). Other coagulation and hemogram values did not change in both groups. Erdosteine may have a dualistic effect on the coagulation cascade through its different metabolites.
Authors
- Süleyman Oktar (ORCID: https://orcid.org/0000-0003-0151-5981)
- Sedat Motor (ORCID: https://orcid.org/0000-0003-1004-8086)
- Mesut Demirköse (ORCID: https://orcid.org/0000-0003-3862-4567)
- Ersin Şükrü Erden (ORCID: https://orcid.org/0000-0003-3712-1191)
- S.S. Doğru
Institutions
- University of Health Science (KH)
- Ankara Atatürk Eğitim ve Araştırma Hastanesi (TR)
- Chest Diseases Hospital (KW)
- Ankara Spine Center (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Mustafa Kemal University (TR)
- Gaziantep University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Sovremennye tehnologii v medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.17691/stm2024.16.4.06
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00