Efficacy of a Multi-lamellar Emulsion Containing a Synthetic Sphingosine Kinase 1 Activator and Pseudoceramide in Patients with Atopic Dermatitis: A Randomized Controlled Trial
Combined therapy with the MLE containing Defensamide™ and PC-9S and with topical corticosteroid demonstrated superior clinical outcomes compared with topical corticosteroid monotherapy. Our findings underscore the potential of MLE-containing formulations as effective adjunctive therapies for AD, offering both objective and subjective symptomatic relief and enhancing patients' quality of life.
Authors
- Hye One Kim (ORCID: https://orcid.org/0000-0001-5846-0008)
- Wonseok Jeong (ORCID: https://orcid.org/0000-0001-8894-1857)
- Jin Seo Park (ORCID: https://orcid.org/0000-0001-7956-4148)
- Bo Young Chung (ORCID: https://orcid.org/0000-0002-2795-0140)
- Dae‐Hwan Kim (ORCID: https://orcid.org/0000-0001-8746-6177)
- Chun Wook Park
- So Yeon Lee (ORCID: https://orcid.org/0000-0003-0444-2079)
- C.Y. Hwang
Institutions
- Hallym University Kangnam Sacred Heart Hospital (KR)
- Komipharm International (South Korea) (KR)
Publication Details
- Journal
- Dermatology and Therapy
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1007/s13555-024-01254-5
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hallym University
- Hallym University Medical Center