Cannabinoid type 2 receptor deficiency leads to Aβ-induced cognitive impairment through promoting microglial sensitivity to Aβ in the prefrontal cortex in mice
CB<sub>2</sub>R deletion led to enhanced neuroinflammatory responses via direct upregulating microglia activation in the prefrontal cortex during the early symptomatic phase of AD mice. CB<sub>2</sub>R modulates prefrontal cortical neuroinflammation, which is essential for regulating cognitive functions such as recognition memory at the early stage of AD.
Authors
- Qiang Jiao (ORCID: https://orcid.org/0000-0002-4725-5284)
- Jingpu Shi
- Bo Wang (ORCID: https://orcid.org/0000-0002-1310-869X)
- Jiaguang Sun (ORCID: https://orcid.org/0000-0002-5884-7939)
- ShuaiChen Li
- XiangBo Meng
- Tong Zhang (ORCID: https://orcid.org/0009-0007-3940-356X)
Institutions
- Hebei Medical University (CN)
- Chinese PLA General Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Xingtai People's Hospital (CN)
- Guangdong Food Industry Research Institute (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.ibneur.2024.08.004
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Beijing Municipal Science and Technology Commission