Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
Among patients with ATTR-CM, treatment with vutrisiran led to a lower risk of death from any cause and cardiovascular events than placebo and preserved functional capacity and quality of life. (Funded by Alnylam Pharmaceuticals; HELIOS-B ClinicalTrials.gov number, NCT04153149.).
Authors
- Olga Azevedo (ORCID: https://orcid.org/0000-0002-6784-3403)
- Ronald Witteles (ORCID: https://orcid.org/0000-0002-3043-1472)
- John L. Berk (ORCID: https://orcid.org/0000-0002-1768-2373)
- Kenichi Tsujita (ORCID: https://orcid.org/0000-0002-4314-259X)
- José González‐Costello (ORCID: https://orcid.org/0000-0002-7437-3630)
- Joshua R. Vest (ORCID: https://orcid.org/0000-0002-7226-9688)
- Steen Hvitfeldt Poulsen (ORCID: https://orcid.org/0000-0002-9586-835X)
- Diego Delgado (ORCID: https://orcid.org/0000-0002-0494-0804)
- Antoine Bondue
- Elena Yureneva
- Marianna Fontana (ORCID: https://orcid.org/0000-0002-9233-9831)
- Zoltán Pozsonyi (ORCID: https://orcid.org/0000-0002-3098-2434)
- Farooq H. Sheikh (ORCID: https://orcid.org/0000-0001-9687-9475)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Katherine L. Boyle
- Mathew S. Maurer (ORCID: https://orcid.org/0000-0001-5400-5008)
- Julian D. Gillmore (ORCID: https://orcid.org/0000-0001-6174-9232)
- Ali Abbas Yılmaz (ORCID: https://orcid.org/0000-0001-7629-2802)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Vincent Algalarrondo (ORCID: https://orcid.org/0000-0001-5971-1235)
- Darae Kim (ORCID: https://orcid.org/0000-0003-3284-0904)
- Nancy Silliman
- Brian Drachman
- Thibaud Damy (ORCID: https://orcid.org/0000-0003-4058-3848)
- Pushkal Garg
- Martha Grogan (ORCID: https://orcid.org/0000-0002-2541-4440)
- Ewa A. Jankowska (ORCID: https://orcid.org/0000-0002-9202-432X)
- Nobuhiro Tahara (ORCID: https://orcid.org/0000-0003-2011-8201)
- Jörg Täubel (ORCID: https://orcid.org/0000-0002-0010-207X)
- Caroline Morbach (ORCID: https://orcid.org/0000-0002-0920-6094)
- Andrew Slugg
- Jihong Chen (ORCID: https://orcid.org/0000-0002-8385-193X)
- Peter van der Meer
- Satish A. Eraly
- Lilli Yang
- Andrew Jabbour
- Mark C Petrie
Institutions
- British Heart Foundation (GB)
- University College London (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1056/nejmoa2409134
- Citations
- 302
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 70.61
Funders
- Alnylam Pharmaceuticals