Inhibition of Myeloperoxidase to Treat Left Ventricular Dysfunction in Non-Ischaemic Cardiomyopathy
Myeloperoxidase predicts long-term outcome in HFrEF and its inhibition elicits systemic anti-inflammatory and vasodilating effects which translate into improved left ventricular function. MPO inhibition deserves further evaluation as a novel, complementary treatment strategy for HFrEF.
Authors
- Holger Winkels (ORCID: https://orcid.org/0000-0003-1333-2031)
- Aleksandra Trifunović (ORCID: https://orcid.org/0000-0002-5472-3517)
- Norbert Gerdes (ORCID: https://orcid.org/0000-0002-4546-7208)
- Malte Kelm (ORCID: https://orcid.org/0000-0003-0060-1052)
- Volker Rudolph (ORCID: https://orcid.org/0000-0001-5385-6839)
- Sven Witkowski (ORCID: https://orcid.org/0000-0001-5398-7572)
- Marcus Krüger (ORCID: https://orcid.org/0000-0002-5846-6941)
- Simon Braumann (ORCID: https://orcid.org/0000-0002-9969-6073)
- Alexander C. Bunck (ORCID: https://orcid.org/0000-0003-0986-0042)
- Philipp S. Wild (ORCID: https://orcid.org/0000-0003-4413-9752)
- Simon Geißen (ORCID: https://orcid.org/0000-0002-7835-4111)
- Felix Sebastian Nettersheim (ORCID: https://orcid.org/0000-0002-4090-3357)
- Martin Hellmich (ORCID: https://orcid.org/0000-0001-5174-928X)
- Dennis Mehrkens (ORCID: https://orcid.org/0000-0002-8578-0290)
- Stephan Baldus
- Martin Mollenhauer (ORCID: https://orcid.org/0000-0002-3220-9269)
- Lea Isermann (ORCID: https://orcid.org/0000-0003-3319-3999)
- Philipp von Stein (ORCID: https://orcid.org/0000-0003-4548-3897)
- Alexander Hof (ORCID: https://orcid.org/0000-0001-6554-8892)
- Vincent ten Cate (ORCID: https://orcid.org/0000-0003-3285-8442)
- Stephan Rosenkranz (ORCID: https://orcid.org/0000-0001-6237-1470)
- Frederik Tellkamp (ORCID: https://orcid.org/0000-0002-0473-7320)
- Henning Guthoff (ORCID: https://orcid.org/0000-0002-0979-1190)
- Gregor Buch (ORCID: https://orcid.org/0000-0002-9963-1245)
- Anna Klinke (ORCID: https://orcid.org/0000-0002-1118-4082)
- Matti Adam
- Joana Adler
Institutions
- TH Köln - University of Applied Sciences (DE)
- University of Cologne (DE)
- Johannes Gutenberg University Mainz (DE)
- Heart and Diabetes Center North Rhine-Westphalia (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1002/ejhf.3435
- Citations
- 4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- European Society of Cardiology
- Deutsche Forschungsgemeinschaft
- Center for Molecular Medicine Cologne, University of Cologne