Utilizing an acute hyperthermia‐induced seizure test and pharmacokinetic studies to establish optimal dosing regimens in a mouse model of Dravet syndrome
A polypharmacy strategy may be a practical preclinical approach to identifying efficacious compounds for DS. The drug-drug interactions between compounds used in this study may explain the potentiated efficacy of some polytherapies.
Authors
- Christopher A. Reilly (ORCID: https://orcid.org/0000-0002-5006-1982)
- Kristina Johnson
- Jeffrey A. Mensah (ORCID: https://orcid.org/0000-0001-7026-9329)
- Cameron S. Metcalf (ORCID: https://orcid.org/0000-0002-1510-0405)
- Joseph E. Rower (ORCID: https://orcid.org/0000-0003-3629-7902)
- Karen S. Wilcox (ORCID: https://orcid.org/0000-0003-2660-8826)
- Tia Freeman
Institutions
- University of Utah (US)
- National Institute of Neurological Disorders and Stroke (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1111/epi.18104
- Citations
- 5
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke