New Meroterpenes from South China Sea Soft Coral Litophyton brassicum

A chemical investigation of the extracts from the soft coral <i>Litophyton brassicum</i> led to the isolation and identification of four new meroterpenes, brassihydroxybenzoquinone A and B (<b>1</b> and <b>2</b>) and brassinaphthoquinone A and B (<b>3</b> and <b>4</b>), along with two known related meroterpenes (<b>5</b> and <b>6</b>). Their structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR) spectroscopy, and a comparison with the literature data. All compounds were evaluated for antibacterial activity against six pathogenic bacterial strains and for cytotoxic activity against three cancer cell lines. In the cytotoxic assay, all compounds were inactive at 10 μM against the A549, HeLa, and MDA-MB-231 cell lines. In the antibacterial assay, compounds <b>1</b> and <b>2</b> exhibited moderate inhibitory activity with minimum inhibitory concentrations (MIC) ranging from 8 to 64 μg/mL.

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Publication Details

Journal
Marine Drugs
Published
2024-08-30
DOI
https://doi.org/10.3390/md22090392
Citations
6
Primary Topic
Marine Sponges and Natural Products
Type
article
Field-Weighted Citation Impact
2.32

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article

New Meroterpenes from South China Sea Soft Coral Litophyton brassicum

Wenhan Lin, Xiaoyi Chen, Han Ouyang, Shan He et al.
6 citations
Marine Drugs
Marine Sponges and Natural Products
2.32
article

New Meroterpenes from South China Sea Soft Coral Litophyton brassicum

Wenhan Lin, Xiaoyi Chen, Han Ouyang, Shan He, Bing Keong Li, Jiahui Zhang, Te Li, Jiayu Yang, Xia Yan, Hongyu Hu
article en
6 citations

Abstract

A chemical investigation of the extracts from the soft coral <i>Litophyton brassicum</i> led to the isolation and identification of four new meroterpenes, brassihydroxybenzoquinone A and B (<b>1</b> and <b>2</b>) and brassinaphthoquinone A and B (<b>3</b> and <b>4</b>), along with two known related meroterpenes (<b>5</b> and <b>6</b>). Their structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR) spectroscopy, and a comparison with the literature data. All compounds were evaluated for antibacterial activity against six pathogenic bacterial strains and for cytotoxic activity against three cancer cell lines. In the cytotoxic assay, all compounds were inactive at 10 μM against the A549, HeLa, and MDA-MB-231 cell lines. In the antibacterial assay, compounds <b>1</b> and <b>2</b> exhibited moderate inhibitory activity with minimum inhibitory concentrations (MIC) ranging from 8 to 64 μg/mL.

Marine DrugsVol. 22(9)
Ningbo University (CN), Zhejiang Normal University (CN), Peking University (CN)
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, Chinese Academy of Sciences, Ningbo University, Higher Education Discipline Innovation Project, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Institute of Oceanology, Chinese Academy of Sciences
Life below water
Openalex Percentile: Top 13%
Marine Sponges and Natural Products
2.32
DOIOpen Access PDFOpenAlex
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