Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy
Oral TRF therapy for 12 weeks lowers retinal cell apoptosis by decreasing pro- and increasing anti-apoptotic markers. The preservation of visual behaviour in a two-chamber mirror test supported these retinal molecular alterations in diabetic rats.
Authors
- Nafeeza Mohd Ismail
- Igor Iezhitsa (ORCID: https://orcid.org/0000-0002-2852-8486)
- Heethal Jaiprakash (ORCID: https://orcid.org/0000-0001-9948-4428)
- Muhammad Zulfiqah Sadikan (ORCID: https://orcid.org/0000-0003-1216-8217)
- Renu Agarwal (ORCID: https://orcid.org/0000-0002-3050-7449)
- Nurul Alimah Abdul Nasir (ORCID: https://orcid.org/0000-0002-4285-7059)
- You Goh (ORCID: https://orcid.org/0000-0001-6640-0240)
Institutions
- Volgograd State Medical University (RU)
- Manipal University College Malaysia (MY)
- IMU University (MY)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s12906-024-04614-y
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Medical University