UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C
The highly conserved 2C protein of EV-A71 is a multifunctional protein and plays a key role in the replication cycle. In this study, we demonstrated for the first time that UBE3C promoted the degradation of 2C K268 <i>via</i> K33/K48-linked ubiquitination, thereby inhibiting viral proliferation. Our findings advance the knowledge related to the roles of 2C in EV-A71 virulence and the ubiquitination pathway in the host restriction of EV-A71 infection.
Authors
- Haiyan Yan (ORCID: https://orcid.org/0009-0000-8780-2601)
- Boming Cui
- Yuhuan Li (ORCID: https://orcid.org/0000-0003-3725-3258)
- Shuo Wu (ORCID: https://orcid.org/0000-0002-9443-5704)
- Huiqiang Wang (ORCID: https://orcid.org/0000-0002-5956-077X)
- Ge Yang (ORCID: https://orcid.org/0000-0002-5085-4261)
- Kun Wang (ORCID: https://orcid.org/0000-0002-4865-1430)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1128/jvi.01335-24
- Citations
- 2
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.10
Funders
- National Natural Science Foundation of China