Empagliflozin in Acute Myocardial Infarction Reduces No-Reflow and Preserves Cardiac Function by Preventing Endothelial Damage
Empagliflozin treatment before acute myocardial infarction mainly targets the endothelial cell transcriptome. Empagliflozin treatment before and after myocardial infarction decreased no reflow and microvascular injury, leading to reduced infiltration of inflammatory cells, reduced infarct size, and improved cardiac function in mice. In diabetic patients receiving empagliflozin after myocardial infarction, perfused boundary region, flow-mediated dilation, and global longitudinal strain were improved.
Authors
- Nikolaos Kostomitsopoulos (ORCID: https://orcid.org/0000-0003-4787-5106)
- Yannis L. Loukas
- Ioanna Andreadou (ORCID: https://orcid.org/0000-0003-1504-9942)
- Michael Pieper (ORCID: https://orcid.org/0000-0003-1348-5927)
- Lara S. F. Konijnenberg (ORCID: https://orcid.org/0000-0002-2634-2864)
- Dimitris Grigoriadis (ORCID: https://orcid.org/0000-0002-2386-5272)
- Panagiota Nikolaou (ORCID: https://orcid.org/0000-0002-7777-6726)
- Marios Miliotis (ORCID: https://orcid.org/0000-0003-4924-050X)
- Tom T J Luiken
- Ignatios Ikonomidis (ORCID: https://orcid.org/0000-0001-8241-7886)
- Coert J. Zuurbier (ORCID: https://orcid.org/0000-0001-8361-2448)
- Ioannis V. Kostopoulos (ORCID: https://orcid.org/0000-0003-1152-6959)
- N Orologas
- George Pavlidis (ORCID: https://orcid.org/0000-0003-3220-3446)
- Niels van Royen (ORCID: https://orcid.org/0000-0001-6136-8640)
- G Pallot (ORCID: https://orcid.org/0000-0001-7961-0685)
- Carolien Kuster (ORCID: https://orcid.org/0009-0009-7200-0759)
- Anna Agapaki (ORCID: https://orcid.org/0000-0002-7591-3547)
- Nikolaos Mylonas
- Ourania Tsitsilonis (ORCID: https://orcid.org/0000-0001-6954-0740)
- Anastasios D. Georgoulis
- Robin Nijveldt (ORCID: https://orcid.org/0000-0003-1530-6363)
- Yannis Dotsikas (ORCID: https://orcid.org/0000-0003-0882-8286)
- Artemis G. Hatzigeorgiou (ORCID: https://orcid.org/0000-0003-1414-5668)
- Pierre Boucher (ORCID: https://orcid.org/0009-0006-2761-4004)
- Rona Roverts
- Vince P A van Reijmersdal
- Stéphane Germain
Institutions
- Centre National de la Recherche Scientifique (FR)
- Boehringer Ingelheim (Germany) (DE)
- University of Thessaly (GR)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Radboud University Medical Center (NL)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Centre Interdisciplinaire de Recherche en Biologie (FR)
- University of Amsterdam (NL)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jacbts.2024.08.003
- Citations
- 16
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 6.43
Funders
- European Cooperation in Science and Technology
- National and Kapodistrian University of Athens