Association of post-operative ctDNA detection with outcomes of patients with early breast cancers
In patients with treatment-naive EBC, ctDNA is detectable after surgery. The absence of ctDNA at a single post-surgical timepoint is associated with improved DRFS, supporting the development of future trials studying de-escalation of systemic therapy.
Authors
- Alistair Ring (ORCID: https://orcid.org/0000-0003-1230-2973)
- A. Okines
- Isaac García-Murillas (ORCID: https://orcid.org/0000-0001-8183-7969)
- Minetta C. Liu (ORCID: https://orcid.org/0000-0002-8206-5232)
- Peter Barry (ORCID: https://orcid.org/0000-0003-0809-7452)
- M Robert (ORCID: https://orcid.org/0000-0002-6711-2942)
- Rosalind Cutts (ORCID: https://orcid.org/0000-0002-8297-9341)
- Ekaterina Kalashnikova (ORCID: https://orcid.org/0000-0003-1078-0656)
- Sarah Hrebien
- Himanshu Sethi (ORCID: https://orcid.org/0000-0002-5787-8901)
- Alexey Aleshin (ORCID: https://orcid.org/0000-0002-0425-0301)
- Matthew Beaney (ORCID: https://orcid.org/0009-0004-9418-2120)
- Scott Dashner (ORCID: https://orcid.org/0009-0004-7364-5130)
- Catey Bunce (ORCID: https://orcid.org/0000-0002-0935-3713)
- N.C. Turner
- Maria Coakley (ORCID: https://orcid.org/0000-0003-2658-7789)
- Ian E. Smith
- G W Crestani
- H.-T. Wu
- Lara Ulrich
Institutions
- Breast Cancer Now (GB)
- Institut de Cancérologie de l'Ouest (FR)
- Royal Marsden Hospital (GB)
- Natera (United States) (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103687
- Citations
- 23
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.56
Funders
- National Institute for Health and Care Research