Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma
Asn enrichment and mTORC1 upregulation are important factors contributing to WD/DD LPS tumor progression. Effective targeting strategies require limiting access to extracellular Asn and inhibition of de novo synthesis mechanisms. The combination of PEG-Asnase with ETC inhibition is an effective therapy to restrict tumor growth in WD/DD LPS.
Authors
- Tyler R. McCaw (ORCID: https://orcid.org/0000-0003-4097-1111)
- Serena Lofftus
- Blake R. Wilde (ORCID: https://orcid.org/0000-0002-8372-3954)
- Thomas G. Graeber (ORCID: https://orcid.org/0000-0001-8574-9181)
- Heather R. Christofk (ORCID: https://orcid.org/0000-0002-8662-4425)
- Nedas Matulionis (ORCID: https://orcid.org/0000-0001-7624-3090)
- Brian E. Kadera (ORCID: https://orcid.org/0000-0002-5133-8656)
- Sarah Dry (ORCID: https://orcid.org/0000-0002-1858-5225)
- Danielle S. Graham (ORCID: https://orcid.org/0000-0003-4839-1250)
- David B. Shackelford (ORCID: https://orcid.org/0000-0002-8270-898X)
- Fritz C. Eilber
- Kyle D. Klingbeil (ORCID: https://orcid.org/0000-0002-4359-5556)
- Joseph G. Crompton (ORCID: https://orcid.org/0000-0001-9325-2909)
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3390/cancers16173031
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86