Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome
While inflammation, pTau, and Aβ are all involved in AD pathology, their contribution to disease progression may differ depending on the diagnosis. Our results suggest that DS-AD and EOAD may be more similar in pathology than LOAD. Our study highlights unique avenues to further our understanding of the mechanisms governing AD neuropathology.
Authors
- Aurélie Ledreux (ORCID: https://orcid.org/0000-0001-6232-7672)
- Ann‐Charlotte Granholm (ORCID: https://orcid.org/0000-0002-9685-7599)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Hannah Saternos
- Eric D. Hamlett (ORCID: https://orcid.org/0000-0002-2900-7949)
- Samuel J. Guzman (ORCID: https://orcid.org/0000-0001-7029-978X)
Institutions
- Medical University of South Carolina (US)
- University of California, Irvine (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3233/jad-240043
- Citations
- 2
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- BrightFocus Foundation
- National Institutes of Health
- National Institute on Aging