Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy after Bile and Stone Spillag

Objective: To determine the role of postoperative antibiotics in patients who had bile and stone spillage during laparoscopic cholecystectomy in terms of rate of postoperative surgical site infection and readmission. Study Design: Quasi experimental study. Place and Duration of Study: Surgical Department of Pak Emirates Military Hospital, Rawalpindi Pakistan, from Apr to Sep 2022. Methodology: A total of 166 patients fulfilling the selection criteria were enrolled after taking written informed consent and were divided into two groups i.e. 83 each by odd and even number. Patients in Group-A received postoperative antibiotics and in Group-B did not have antibiotics and the outcome measures were assessed while the patients remained admitted and then weekly until day 30th. Results: The mean age in the Groups A versus B was 41.27±7.05 versus 41.31±6.14 years and mean duration of hospital stay was 2.48±0.95 versus 2.59±0.81 days, respectively. In Group-A versus B, postoperative infections were present in 2(2.4%) versus 3(3.6%) (p=0.650), surgical site infection in 14(16.9%) versus 11(13.3%) (p=0.515) and readmission occurred in 8(10%) versus 6(7.2%) patients (p=0.576), respectively. Conclusion: The rate of surgical site infections, rate of readmission and DOH stay was not significantly different between patients who received postoperative antibiotics compared to those who did not after laparoscopic cholecystectomy.