Degradation of Amyloid-β Species by Multi-Copper Oxidases
To the best of our knowledge, our report is the first to demonstrate that MCOs have a degrading function for peptides/proteins. Further investigations are warranted to explore the possible benefits of MCOs for future AD treatment.
Authors
- Kathleen R. Ran (ORCID: https://orcid.org/0000-0001-5573-7534)
- Wenzhe Ma (ORCID: https://orcid.org/0000-0001-9475-6981)
- Yanxin Chen (ORCID: https://orcid.org/0000-0003-1828-3574)
- Ying Lü (ORCID: https://orcid.org/0000-0002-7698-8962)
- Chongzhao Ran (ORCID: https://orcid.org/0000-0002-3892-4108)
- Hui Ye (ORCID: https://orcid.org/0000-0001-5872-7542)
- Can Zhang (ORCID: https://orcid.org/0000-0002-4340-5118)
- Jing Yang (ORCID: https://orcid.org/0009-0003-2199-8623)
- Y. Iris Chen
Institutions
- Harvard University (US)
- China Pharmaceutical University (CN)
- Loyola University Chicago (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Center for Systems Biology (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3233/jad-240625
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33