Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell–Derived Macrophage-Human Intestinal Organoid Model of Crohn’s Disease
ETYA inhibits profibrotic effects of LPS-primed macrophages upon cocultured HIO. This model may be used in future untargeted screens for small molecules to treat refractory CD.
Authors
- Kentaro Iwasawa (ORCID: https://orcid.org/0000-0002-5387-0099)
- Elizabeth Angerman
- Takanori Takebe (ORCID: https://orcid.org/0000-0002-6989-3041)
- James M. Wells (ORCID: https://orcid.org/0000-0002-1398-848X)
- Lee A. Denson (ORCID: https://orcid.org/0000-0001-8045-7198)
- Kentaro Tominaga (ORCID: https://orcid.org/0000-0001-6792-1005)
- Ingrid Jurickova
- Benjamin W. Dreskin (ORCID: https://orcid.org/0000-0003-1009-7574)
- Michael A. Helmrath (ORCID: https://orcid.org/0000-0003-3112-7541)
- Erin Bonkowski (ORCID: https://orcid.org/0000-0003-4798-1347)
- Jack Nguyen
- Richard Villarreal
- Yael Haberman
- Tzipi Braun
Institutions
- Tokyo Medical and Dental University (JP)
- Cincinnati Children's Hospital Medical Center (US)
- Tel Aviv University (IL)
- Sheba Medical Center (IL)
- University of Cincinnati (US)
- Niigata University (JP)
- University of Cincinnati Medical Center (US)
- The University of Osaka (JP)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae139
- Citations
- 3
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- Cincinnati Children's Hospital Medical Center
- Kenneth Rainin Foundation
- Crohn's and Colitis Foundation
- National Institutes of Health