Synergistic efficacy of ceftazidime/avibactam and aztreonam against carbapenemase-producing <i>Pseudomonas aeruginosa</i> : insights from the hollow-fiber infection model
The combination of CZA and aztreonam significantly enhanced the <i>in vitro</i> efficacy against XDR <i>P. aeruginosa</i> isolates compared to each monotherapy. This improvement suggests that the combination could serve as a feasible treatment alternative for infections caused by carbapenemase-producing XDR <i>P. aeruginosa</i>, especially in scenarios where no other treatment options are available.
Authors
- Antonio Oliver (ORCID: https://orcid.org/0000-0001-8571-2733)
- Juan Pablo Horcajada (ORCID: https://orcid.org/0000-0001-9873-5459)
- Sònia Luque (ORCID: https://orcid.org/0000-0002-3215-320X)
- Luisa Sorlí (ORCID: https://orcid.org/0000-0001-9562-514X)
- Sandra Domene-Ochoa (ORCID: https://orcid.org/0000-0003-4315-9794)
- M. Montero (ORCID: https://orcid.org/0000-0001-5991-6804)
- Núria Prim
- Carla López-Causapé (ORCID: https://orcid.org/0000-0003-2228-2005)
- Daniel Echeverría-Esnal (ORCID: https://orcid.org/0000-0003-4975-8798)
- Eduardo Padilla (ORCID: https://orcid.org/0000-0002-3960-8641)
- Eliana Ferola
- Victoria Vega-Toribio
- Mario F. Ampuero Morisaki
Institutions
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Health Research Institute of the Balearic Islands (ES)
- Hospital Del Mar (ES)
- Hospital Universitario Son Espases (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Infectious Diseases
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1080/23744235.2024.2396882
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- European Commission
- Ministerio de Economía y Competitividad
- Instituto de Salud Carlos III