Identification of the Shared Gene Signatures Between Alzheimer’s Disease and Diabetes-Associated Cognitive Dysfunction by Bioinformatics Analysis Combined with Biological Experiment
This study is the first to use bioinformatics tools to uncover the genetic link between AD and DACD. GAD1, UCHL1, GAP43, CARNS1, TAGLN3, and SH3GL2 were identified as key genes connecting AD and DACD. These findings offer new insights into the diseases' pathogenesis and potential diagnostic and therapeutic targets.
Authors
- Zhijun Bao (ORCID: https://orcid.org/0000-0002-0900-7204)
- Xueying Ji
- Yixin Chen (ORCID: https://orcid.org/0000-0002-4965-8976)
Institutions
- Fudan University (CN)
- Huadong Hospital (CN)
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3233/jad-240353
- Citations
- 3
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China