Construction and analysis of a lysosome-dependent cell death score-based prediction model for non-small cell lung cancer
The study showed a significant increase in the proportion of monocytes in NSCLC tissues, suggesting their important role in cancer progression. Cell communication analysis indicated that macrophages, smooth muscle cells, and myeloid cells exhibit strong intercellular communication during cancer progression. Using the constructed prognostic model based on 12 LDCD-related genes, we found significant differences in overall survival and immune microenvironment between the high-risk and low-risk groups.
Authors
- Youshu Gao
- Yaohua Chen (ORCID: https://orcid.org/0000-0003-1778-1790)
- Ming Tan (ORCID: https://orcid.org/0000-0001-6565-699X)
- Jie Li (ORCID: https://orcid.org/0000-0002-6912-3346)
- Jiang Wang (ORCID: https://orcid.org/0000-0002-0085-9056)
- Pingfei Wang
- Rui Lin (ORCID: https://orcid.org/0000-0002-3846-9301)
- Maoshu Bai (ORCID: https://orcid.org/0000-0003-4546-8849)
- Guirong Wu (ORCID: https://orcid.org/0009-0005-9778-8088)
- Jiangping Fu
- Fang Wu (ORCID: https://orcid.org/0000-0003-3806-1872)
- Yao Rao
- Fudao Wu
Institutions
- Guangxi Medical University (CN)
- First People’s Hospital of Jingmen (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Xian Yang Central Hospital (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1007/s12672-024-01233-4
- Citations
- 3
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.26