A GENOME-WIDE CRISPR/CAS9 SCREEN REVEALS EPIGENETIC IMMUNE EVASION MECHANISMS IN HUMAN PAPILLOMAVIRUS-POSITIVE HEAD AND NECK SQUAMOUS CELL CARCINOMA
By Nicholas Giacobbi. Human papillomavirus-positive head and neck squamous cell carcinoma has limited expression of MHC-I molecules for antigen presentation, resulting in immune evasion and limited efficacy of immune checkpoint inhibitor therapy.
Authors
- Lexi Vu (ORCID: https://orcid.org/0000-0001-9243-7469)
- Andrew J. Olive (ORCID: https://orcid.org/0000-0003-3441-3113)
- Shreya Mullapudi (ORCID: https://orcid.org/0009-0007-2112-2882)
- Dohun Pyeon (ORCID: https://orcid.org/0000-0003-1970-844X)
- Mohamed Ibrahim Khalil (ORCID: https://orcid.org/0000-0002-8331-1490)
- Nicholas S. Giacobbi
- Canchai Yang (ORCID: https://orcid.org/0000-0002-0125-9298)
- Niklas Alexander Wahl
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Spartan Medical Research Journal
- Published
- 2024-08-30
- DOI
- https://doi.org/10.51894/001c.122809
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00