Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels
Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits.
Authors
- José Carlos Rodríguez‐Cabello (ORCID: https://orcid.org/0000-0002-3438-858X)
- Matilde Alonso (ORCID: https://orcid.org/0000-0002-6853-8427)
- Liliana R. Missana (ORCID: https://orcid.org/0000-0002-7760-4684)
- Sara Feldman (ORCID: https://orcid.org/0000-0001-9804-8421)
- Mariangeles Aimone
- Arturo Ibáñez‐Fonseca (ORCID: https://orcid.org/0000-0002-2223-5041)
- Michael Stur
- Diana Juanes‐Gusano
- Octavio Santiago (ORCID: https://orcid.org/0009-0004-0163-1303)
- Iván Nadir Camal Ruggieri (ORCID: https://orcid.org/0000-0001-5708-9462)
- João Paulo Mardegan Issa
Institutions
- Universidad de Valladolid (ES)
- National University of Tucumán (AR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National University of Rosario (AR)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Centro Científico Tecnólogico - Rosario (AR)
- Centro Científico Tecnológico - Tucumán (AR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1038/s41598-024-69658-z
- Citations
- 6
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- Universidad Nacional de Rosario
- Junta de Castilla y León
- Centro en Red de Medicina Regenerativa y Terapia celular de Castilla y León