Colchicine prevents accelerated atherosclerosis in <i>TET2</i>-mutant clonal haematopoiesis
These results highlight the potential value of colchicine to mitigate the higher cardiovascular risk of carriers of somatic TET2 mutations in blood cells. These observations set the basis for the development of clinical trials that evaluate the efficacy of precision medicine approaches tailored to the effects of specific mutations linked to CH.
Authors
- Virginia Zorita (ORCID: https://orcid.org/0009-0003-1527-9737)
- Md Mesbah Uddin (ORCID: https://orcid.org/0000-0003-1846-0411)
- Nuria Matesanz (ORCID: https://orcid.org/0000-0002-5756-3424)
- Michael C. Honigberg (ORCID: https://orcid.org/0000-0001-8630-5021)
- Zhi Yu (ORCID: https://orcid.org/0000-0003-4810-3474)
- Marta Amorós-Pérez (ORCID: https://orcid.org/0000-0003-0025-0731)
- Abhishek Niroula (ORCID: https://orcid.org/0000-0002-5904-0635)
- Pradeep Natarajan (ORCID: https://orcid.org/0000-0001-8402-7435)
- M. Lopez
- Buu Minh Thanh Truong (ORCID: https://orcid.org/0000-0003-0043-0812)
- Tetsushi Nakao (ORCID: https://orcid.org/0000-0001-9979-2682)
- Domingo A. Pascual‐Figal (ORCID: https://orcid.org/0000-0002-4993-9540)
- Benjamin L. Ebert (ORCID: https://orcid.org/0000-0003-0197-5451)
- María A. Zuriaga (ORCID: https://orcid.org/0000-0003-0422-2965)
- Rosa Moro
- José J. Fuster (ORCID: https://orcid.org/0000-0002-5970-629X)
- Beatriz López Ramos-Neble
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Science for Life Laboratory (SE)
- Lemuel Shattuck Hospital (US)
- Spanish National Centre for Cardiovascular Research (ES)
- Massachusetts General Hospital (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Dana-Farber Cancer Institute (US)
- Spanish National Centre for Cardiovascular Research (ES)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Center for Genomic Science (IT)
- Universidad de Murcia (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1093/eurheartj/ehae546
- Citations
- 58
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 26.35
Funders
- American Heart Association
- Fundació la Marató de TV3
- Ministerio de Ciencia, Innovación y Universidades
- Fondation Leducq
- Japan Society for the Promotion of Science
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute