Stakeholder-informed positivity thresholds for disease markers and risk scores: a methodological framework and an application in obstructive lung disease
The proposed methodology can be applied to many contexts where the objective is to devise positivity thresholds that need to incorporate stakeholder preferences. Applying this framework to chronic obstructive pulmonary disease pharmacotherapy resulted in a stakeholder-informed treatment threshold that was substantially lower than the implicit thresholds in contemporary guidelines.
Authors
- Mohsen Sadatsafavi (ORCID: https://orcid.org/0000-0002-0419-7862)
- Amir Khakban
- Nick Bansback (ORCID: https://orcid.org/0000-0002-1510-3462)
- Samir Gupta (ORCID: https://orcid.org/0000-0003-2656-3912)
- Tima Mohammadi
Institutions
- St. Michael's Hospital (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- St. Paul's Hospital (CA)
- Centre for Advancing Health Outcomes (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.jclinepi.2024.111509
- Citations
- 1
- Primary Topic
- Community Development and Social Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Michael Smith Health Research BC
- Canadian Institutes of Health Research