Difference in gut microbial dysbiotic patterns between body-first and brain-first Parkinson's disease
Our findings highlight the significant role of dysbiotic and pathogenic gut microbial alterations in body-first PD, supporting the body-first versus brain-first hypothesis. These insights not only reinforce the gut microbiome's potential as a therapeutic target in PD but also suggest the possibility of developing subtype-specific treatment strategies.
Authors
- In-Ja Shin
- Hyun‐Seok Oh (ORCID: https://orcid.org/0000-0001-8560-7132)
- Woorim Kang (ORCID: https://orcid.org/0009-0005-1604-5785)
- Don Gueu Park (ORCID: https://orcid.org/0000-0001-8658-3523)
- Jung Han Yoon (ORCID: https://orcid.org/0000-0001-6180-9848)
- Mauricio Chalita (ORCID: https://orcid.org/0000-0002-2173-6688)
- Young‐Sil An (ORCID: https://orcid.org/0000-0003-0777-6226)
- Dong‐Wook Hyun
- Jongsik Chun (ORCID: https://orcid.org/0000-0003-3385-5171)
- Eun Jeong Lee (ORCID: https://orcid.org/0000-0002-3507-5550)
- Hyun Kim
Institutions
- Ajou University (KR)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.nbd.2024.106655
- Citations
- 22
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.12
Funders
- Ministry of Science, ICT and Future Planning
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea