Causal association of menstrual reproductive factors on the risk of osteoarthritis: A univariate and multivariate Mendelian randomization study
This research Certificates that Early AFB promotes the development of OOA, meanwhile early AFB, ALB, and AFSI are also risk factors of KOA. Reproductive factors, especially those related to birth, may have the greatest impact on KOA. It provides guidance for promoting women's appropriate age fertility and strengthening perinatal care.
Authors
- Yixiao Han
- Pengqi Zhang (ORCID: https://orcid.org/0000-0001-8016-6307)
- Yihao Zhou (ORCID: https://orcid.org/0000-0002-3779-9907)
- Zhichao Liao (ORCID: https://orcid.org/0000-0003-3279-1161)
- Xinzhe Tan (ORCID: https://orcid.org/0009-0001-3738-6176)
- Dongyan Wang (ORCID: https://orcid.org/0000-0001-5273-1145)
- Yifang Mei
- Yichang Liu
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1371/journal.pone.0307958
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94