Dietary apigenin ameliorates obesity-related hypertension through TRPV4-dependent vasorelaxation and TRPV4-independent adiponectin secretion
Our study indicates that dietary apigenin is suitable as a nonpharmaceutical intervention for obesity-related hypertension. In mechanism, in addition to improving vascular relaxation through the activation of endothelial TRPV4 channels, apigenin also directly alleviated adipose inflammation and increased adiponectin levels by inhibiting CD38.
Authors
- Zongshi Lu (ORCID: https://orcid.org/0000-0002-2434-8832)
- Aidi Mou
- Tingbing Cao
- Qing Zhou (ORCID: https://orcid.org/0000-0003-2096-1960)
- Jie Xiang (ORCID: https://orcid.org/0000-0003-2264-7625)
- Peng Gao (ORCID: https://orcid.org/0000-0001-6145-7440)
- Zhiming Zhu (ORCID: https://orcid.org/0000-0003-1035-5588)
- Li Li (ORCID: https://orcid.org/0000-0002-9496-2280)
- Lijuan Wang (ORCID: https://orcid.org/0000-0003-1727-2670)
- Xiaorong Chen (ORCID: https://orcid.org/0000-0001-6769-8843)
- Hongbo He (ORCID: https://orcid.org/0000-0002-4456-644X)
- Daoyan Liu (ORCID: https://orcid.org/0009-0005-1192-1440)
- Dan Tong (ORCID: https://orcid.org/0000-0002-3551-2861)
- Mei You
- Fang Sun
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.bbadis.2024.167488
- Citations
- 7
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Army Medical University
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission